BJSM

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER


[Advanced]
Published Online First: 3 July 2007. doi:10.1136/bjsm.2007.039040
British Journal of Sports Medicine 2008;42:250-254
Copyright © 2008 BMJ Publishing Group Ltd & British Association of Sport and Exercise Medicine
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
bjsm.2007.039040v1
42/4/250    most recent
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this link to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Add article to my folders
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Arlettaz, A
Right arrow Articles by De Ceaurriz, J
PubMed
Right arrow PubMed Citation
Right arrow Articles by Arlettaz, A
Right arrow Articles by De Ceaurriz, J
Topic Collections
Right arrowRelated Articles

ORIGINAL ARTICLES

Effects of acute prednisolone administration on exercise endurance and metabolism

A Arlettaz1, K Collomp1,2, H Portier1, A-M Lecoq1,3, N Rieth1, B Le Panse1, J De Ceaurriz2

1 LAPSEP, Faculty of Sport Science, University of Orléans, Orléans, France
2 Département des Analyses, AFLD,Chatenay-Malabry, France
3 Sports Medicine Service, CHR Orléans, France

Correspondence to:
K Collomp, LAPSEP, UFR STAPS, 2, Allée du Château, BP6237 45062 Orléans Cedex 2, France; katia.collomp{at}univ-orleans.fr

Objective: To examine whether acute glucocorticoid (GC) intake alters performance and selected hormonal and metabolic variables during submaximal exercise.

Methods: In total, 14 recreational male athletes completed two cycling trials at 70–75% maximum O2 uptake starting 3 h after an ingestion of either a lactose placebo or oral GC (20 mg of prednisolone) and continuing until exhaustion, according to a double-blind randomised protocol. Blood samples were collected at rest, after 10, 20, 30 minutes, and at exhaustion and recovery for measurement of growth hormone (GH), adrenocorticotropic hormone (ACTH), dehydroepiandrosterone (DHEA), prolactin, insulin, blood glucose, lactate and interleukin (IL)-6 determination.

Results: Cycling duration was not significantly changed after GC or placebo administration (55.9 (5.2) v 48.8 (2.9) minutes, respectively). A decrease in ACTH and DHEA (p<0.01) was observed with GC during all of the experiments and in IL-6 after exhaustion (p<0.05). No change in basal, exercise or recovery GH, prolactin, insulin or lactate was found between the two treatments but blood glucose was significantly higher with GC (p<0.05) at any time point.

Conclusion: From these data, acute systemic GC administration does seem to alter some metabolic markers but did not influence performance during submaximal exercise.

Keywords: glucocorticoid; oral intake; performance; submaximal exercise; hormone


Related Articles

Commentary 1 on "Effects of acute prednisolone administration on exercise endurance and metabolism"
Michel Audran
Br. J. Sports Med. 2008 42: 254. [Extract] [Full Text] [PDF]

Commentary 2 on "Effects of acute prednisolone administration on exercise endurance and metabolism"
L Horta
Br. J. Sports Med. 2008 42: 254. [Extract] [Full Text] [PDF]





HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER
Terms and conditions relating to subscriptions purchased online  ¦  Website terms and conditions  ¦  Privacy policy
Copyright © 2008 BMJ Publishing Group Ltd & British Association of Sport and Exercise Medicine