Table 4

Effects of glyceryl trinitrate 1.25 mg/day through transdermal patch and rehabilitation versus rehabilitation alone in patients with supraspinatus tendinopathy (adapted from Paoloni et al²⁰)

Week	Active	Placebo	p Value
Pain with activity—by shoulder
	(n = 28)	(n = 28)
2	2.2	2.1	0.80
6	1.9	2.1	0.34
12	1.6	1.9	0.36
24	1.0	1.8	0.006
Pain at rest—by shoulder
	(n = 27)	(n = 28)
2	1.7	1.9	0.47
6	1.5	1.6	0.68
12	1.1	1.4	0.19
24	0.7	1.2	0.09
Pain at night—by shoulder
	(n = 27)	(n = 27)
2	1.4	1.6	0.61
6	1.4	1.5	0.72
12	1.0	1.5	0.09
24	0.8	1.4	0.031
Tenderness—by shoulder
	(n = 27)	(n = 28)
2	0.1	0.4	0.012
6	0.2	0.5	0.017
12	0.2	0.4	0.18
24	0.2	0.2	0.60
Change from baseline in abduction range of motion—by shoulder
	(n = 27)	(n = 29)
2	7.7	1.5	0.15
6	7.8	2.0	0.29
12	16.3	1.2	0.020
24	26.6	8.7	0.004
Change from baseline in adduction power—by shoulder
	(n = 27)	(n = 28)
2	5.6	1.3	0.24
6	7.7	−0.6	0.08
12	11.9	0.4	0.023
24	9.9	1.6	0.11
Change from baseline in external rotation power—by shoulder
	(n = 27)	(n = 28)
2	4.7	0.5	0.17
6	7.4	0.8	0.11
12	11.5	0.5	0.023
24	13.4	0.3	0.013
Change from baseline in external rotation range of motion—by shoulder
	(n = 27)	(n = 27)
2	1.9	6.7	0.13
6	4.7	1.9	0.45
12	7.7	3.3	0.26
24	13.2	8.5	0.17
Change from baseline in forward flexion—by shoulder
	(n = 36)	(n = 41)
2	7.8	0.8	0.11
6	6.5	−2.3	0.09
12	13.4	−2.2	0.019
24	20.3	6.3	0.027
Impingement external rotation (% with 0)—by shoulder
	(n = 27)	(n = 28)
2	40.7	32.1	0.51
6	40.7	32.1	0.57
12	70.4	57.1	0.36
24	70.4	50.0	0.15
Impingement internal rotation (% with 0)—by shoulder
	(n = 27)	(n = 28)
2	33.3	10.7	0.059
6	48.2	17.9	0.040
12	51.9	32.1	0.15
24	74.1	39.3	0.018
Change from baseline in internal rotation power—by shoulder
	(n = 27)	(n = 28)
2	4.9	−0.9	0.14
6	10.8	2.0	0.055
12	11.0	−1.5	0.029
24	13.9	1.1	0.018
Change from baseline in internal rotation range of motion—by shoulder
	(n = 27)	(n = 28)
2	−2.3	0.5	0.37
6	−4.3	−1.0	0.22
12	−5.0	0.6	0.15
24	−8.1	−0.3	0.32
Change from baseline in subscapularis power—by shoulder
	(n = 27)	(n = 28)
2	9.0	0.9	0.009
6	9.2	5.4	0.24
12	14.0	5.8	0.045
24	15.7	6.6	0.018
Change from baseline in supraspinatus power—by shoulder
	(n = 27)	(n = 28)
2	3.6	−1.5	0.10
6	11.0	0.7	0.009
12	15.4	2.0	0.010
24	16.2	2.9	0.007